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NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA
which may result in the restoration of p53 signaling and
Molecular Weight: 1486
CAS Number: 1414854-42-4
InChi: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H
Oclacitinib - CAS# 1208319-26-9 Catalog No.:M9848-2 NS1619 modulates calcium homeostasis inOclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1 dependent cytokines involved in allergy and
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