GDC-0152 ridol (Alvocidib) Smiles: CC(C)(C)C1=NC(=C(S1)C1=CC=NC(N)=N1)C1=CC=CC(NS(=O)(=O)C2C(F)=CC=CC=2F)=C1F

Smiles: CC(C)(C)C1=NC(=C(S1)C1=CC=NC(N)=N1)C1=CC=CC(NS(=O)(=O)C2C(F)=CC=CC=2F)=C1F

05] and a significant effect of KN-62×ZnCl2 treatment interaction [F(1

InChiKey: PXXLQQDIFVPNMP-UHFFFAOYSA-N

857036-77-2 (Cediranib maleate)

InChi: InChI=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3

GDC-0152 ridol (Alvocidib) Smiles: CC(C)(C)C1=NC(=C(S1)C1=CC=NC(N)=N1)C1=CC=CC(NS(=O)(=O)C2C(F)=CC=CC=2F)=C1FGDC 0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC 0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are